xkcd protein folding

This means you're free to copy and share these comics (but not to sell them). Man: ... just folds? The use of game development competitions to assist scientific progress is also used in the Fold.it competitive protein folding game, where the winners build antibodies to save the lives of those who have health care. Credit: xkcd This means you're free to copy and share these comics (but not to sell them). Perhaps create a trivia section? The protein folding problem has been a grand challenge in biology for 50 years. This work is licensed under a Creative Commons Attribution-NonCommercial 2.5 License. When he responds in the affirmative, she then compares the problem of predicting protein folding to creating a living crane by the paper-folding process. If the folding process does not complete, or completes incorrectly, the resulting protein can be … while (true){ This strip from Randall Munroe’s xkcd will be appearing in the lecture. Obligatory XKCD comic here. Protein Folding via xkcd. This means you're free to copy and share these comics (but not to sell them). For more about Protein Folding Xkcd, please subscribe to our website newsletter now! [email protected] ([email protected]) is a distributed computing project which aims to simulate protein folding for research purposes. Boct1584 (talk) 01:46, 20 April 2015 (UTC), I find this explanation a bit too technical. The leader in software by software called folding home. More details.. If each of these bond angles can be in one of three stable conformations, the protein may misfold into a maximum of 3198 different conformations (including any possible folding redundancy). a=false} It can be difficult for the public (or experts for that matter) to grasp the complexity of a task for a computer. This means you're free to copy and share these comics (but not to sell them). This is not an end-to-end AI/Deep Learning protein folding system. some kind of function that only uses any idle memory{ Category Group Rank; Beginner. Having seen the mentions here of forming an xkcd/explainxkcd team, I'm all for it! /r/xkcd is the subreddit for the popular webcomic xkcd by Randall Munroe. More details. Formed: 05/20/08. 27: Puzzle Scores. Rather than the traditional model of using a supercomputer for computation, the project uses idle processing power of a network of personal computers in order to achieve massive computing power. Surely if you were folding yourself a crane out of paper then you would need to fold yourself a pair of scissors in order to be able to make cuts. Get to know more about ketogenic diet and Protein Folding Xkcd here on this site. You'd expect a rising and falling line, but for it to completely trace out building patterns is odd. Note that most modern computers do not "waste" computing time as much as older ones. This paradox is central to computational approaches to protein structure prediction. --141.101.99.49 10:27, 6 October 2014 (UTC), Surely the "pull the tail" is referring to the flapping bird origami, which is similar to the crane but lacks one set of folds that make the figure narrower. I linked to this particular XKCD strip when it came out, but it came right back to mind when I saw this paper, on a new kind of intramolecular interaction in proteins (and other systems).Protein folding, macromolecular folding in general, is indeed a famously horrendous problem to … More details. Alphafold changes everything, fundamentally solving the protein folding problem: predicting how protein chains will fold given an arbitrary sequence of amino acids. Creative Commons Attribution-NonCommercial 2.5 License. This means you're free to copy and share these comics (but not to sell them). We're working with computers and picture, find or discover, often called folding simulation software by software will automatically start up and in mathematics: http: //imgs. This work is licensed under a Creative Commons Attribution-NonCommercial 2.5 License. Description: Folding proteins in the name of sarcasm, romance, math, and language. If the folding process does not complete, or completes incorrectly, the resulting protein can be inactive or even toxic to the body. More details.. Of course, when trying to predict the folding trajectory in nature of a protein A, and one is allowed to make cuts during the process, one is making the assumption that the Protease that cut protein A is already folded and functional. However, since the joke is about folding proteins, this idea is extrapolated to include the folded proteins. xkcd by Randall Munroe (CC BY-NC 2.5). Woman: Imagine figuring out the folds to make an actual living crane. However, prediction can never be as valuable as experimental data. Aiw (talk) 21:38, 6 October 2014 (UTC), I think the last few paragraphs about the simulation program and cpu cycles are unnecessary. Individuals can join the project by installing the [email protected] software (there is also a web version that can be run using Google Chrome) and are then able to track their contribution to the project. Then that line of code could be linked to a boolean that allows the computer to do something vital, like this: if (pr is prime){print pr; "cut") other proteins, often in very specific ways. Protein Folding I am contractually obligated to discuss the basics, the very basic basics, of protein folding with my class over the next week or so. --Pudder (talk) 09:13, 6 October 2014 (UTC), Surely if you were folding yourself a crane out of paper then you would need to fold yourself a pair of scissors in order to be able to make cuts. Individual members may join together as a team, with leaderboards measuring team and individual contributions. Shop for cheap price Xkcd Protein Folding Google Source Code And Natural Protein Bars .Price Low and Options of Xkcd Protein Folding Google Source Code And Natural Protein Bars from variety stores in usa. I don't get it as much... Perhaps something to do with the apparent erratic behavior of a stock market chart? --Pudder (talk) 09:28, 6 October 2014 (UTC), This comic has some similarities to 1425: Tasks. Perhaps move them to comments section. --MGitsfullofsheep (talk) 11:06, 8 October 2014 (UTC), Serious TED talk "protein folding problem: a major conundrum of science": http://youtu.be/zm-3kovWpNQ Jorgbrown (talk) 20:52, 24 February 2015 (UTC), Serious TED talk about advanced math making detailed Origami figurines by doing nothing but folding => http://youtu.be/NYKcOFQCeno Jorgbrown (talk) 20:59, 24 February 2015 (UTC), Going to start using the [email protected] Chrome web applet. Woman: I make software that predicts how proteins will fold. explain xkcd - User contributions [en] Jorgbrown: Shanghai stocks, and the shape of Virginia. Experiments gone wrong? Levinthal's paradox is a thought experiment, also constituting a self-reference in the theory of protein folding. PIs gone AWOL? {{Title text: Check it out--when I tug the C-terminal tail, the binding tunnel squeezes!}} DeepMind, the people who gave us world-beating programs for chess, go, and Asteroids, have created an artificial intelligence system called AlphaFold that predicts the folding of proteins in a few hours. ... From that, we end up with a candidate full-blown protein string. 173.245.52.157 (talk) (please sign your comments with ~~~~), The Title Text made me think of Rembrandt's painting The Anatomy Lesson, where the lecturer was pulling a tendon in a cadaver's forearm, making a finger move. Many people consider this to be more fun, convenient and efficient than donating via credit card. I am contractually obligated to discuss the basics, the very basic basics, of protein folding with my class over the next week or so. bool a=false; The analogy is that a protein cannot just fold to a figurative representation of a bio-molecule, the way a paper crane superficially resembles a live crane; the protein must assume an exact, perfect fold in order to be functional. The C-terminus (end of the protein chain), in this case analogous of the tail, if "pulled" would cause a created cavity or tunnel to squeeze, much like pulling a knot would do the same. Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. They dynamically reduce their clock speed and other power consumption at times of low usage. a=true;} In this comic, Cueball is asking Megan what she does, to which she replies that she works on software to predict protein folding. In this manner, Protease enzymes are analogous to extremely specialized scissors, so Megan is effectively saying "You can make cuts if you can fold yourself a pair of scissors." Man: What do you do? And it’s been solved decades before many researchers antipiated. a=true:} This work is licensed under a 108.162.219.116 (talk) (please sign your comments with ~~~~), Thanks for adding that "your actually donating your electricity" part - I had not considered it to that extent. I realized that the program is using more CPU/GPU "loading" while the screen saver is active, but for some reason I didn't translate that into more money out via my electricity bill. I have added some where it only aims at other science questions. Benjaminikuta (talk) 04:51, 8 October 2014 (UTC), I agree, too. Protein Folding Depletion Forces 1 Depletion Forces 2 Depletion Forces 3 Genetics and Simplicity E=mc^2 Part 1 E=mc^2 Part 2 E=mc^2 Part 3 Symmetry Part 1 Symmetry Part 2 Symmetry Part 3 Feedback Part 1 Feedback Part 2 Feedback Part 3 Quantum Mechanics Part 1 Quantum Mechanics Part 2 The Ultimate Selfish Gene Protein Folding Witnessed Entropy Why I do Science The "paradox" is that most small proteins fold spontaneously on a millisecond or even microsecond time scale. This work is licensed under a Creative Commons Attribution-NonCommercial 2.5 License. Got lab stories? This is true even if conformations are sampled at rapid (nanosecond or picosecond) rates. Protein folding is the process by which proteins, which are floppy, unstructured chains of amino acids when initially synthesized in a cell, assume a stable, functional shape. Cueball asks Megan why it is such a hard computational problem; Megan's response is to ask Cueball if he's ever folded paper to make a crane. That way, if the computer tries to comment out something, it stops working and I might be overthinking this. [[Same scene layout, fourth panel]] The title text refers to the result of folding a flapping bird in origami. But she did not say anything about science. First, let me start off with a couple of caveats.

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